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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
14.85
Human Site:
S337
Identified Species:
25.13
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
S337
E
N
D
D
G
G
F
S
E
E
W
E
A
Q
R
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
Y323
N
A
E
S
R
N
S
Y
L
E
L
R
D
V
S
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
H264
W
E
A
Q
R
D
S
H
L
G
P
H
R
S
T
Dog
Lupus familis
XP_547503
717
78133
A574
M
V
W
T
V
G
M
A
K
L
D
P
S
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S337
G
N
D
D
G
G
F
S
E
E
W
E
A
Q
R
Rat
Rattus norvegicus
P97887
468
52771
S338
G
S
D
D
G
G
F
S
E
E
W
E
A
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
P335
N
R
R
N
R
P
G
P
G
S
I
P
P
Q
R
Chicken
Gallus gallus
Q4JIM4
468
52812
S338
E
A
D
D
G
G
F
S
Q
E
W
Q
Q
Q
R
Frog
Xenopus laevis
O12976
433
48282
Q313
W
E
D
H
R
N
A
Q
I
G
P
I
N
S
T
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
H330
F
T
P
A
W
V
D
H
Q
Q
H
Q
L
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
A358
L
A
S
P
E
A
A
A
A
S
G
Q
R
T
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
T324
E
S
N
T
T
A
S
T
T
Q
N
S
G
V
R
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
D378
Q
E
V
N
G
G
F
D
T
V
F
T
E
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
V330
N
M
E
D
R
E
S
V
M
D
E
E
M
S
P
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
6.6
0
6.6
N.A.
93.3
86.6
N.A.
13.3
73.3
6.6
0
N.A.
0
N.A.
13.3
26.6
P-Site Similarity:
100
13.3
0
33.3
N.A.
93.3
93.3
N.A.
20
86.6
6.6
20
N.A.
13.3
N.A.
40
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
8
8
0
15
15
15
8
0
0
0
22
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
36
36
0
8
8
8
0
8
8
0
8
0
0
% D
% Glu:
22
22
15
0
8
8
0
0
22
36
8
29
8
0
0
% E
% Phe:
8
0
0
0
0
0
36
0
0
0
8
0
0
0
0
% F
% Gly:
15
0
0
0
36
43
8
0
8
15
8
0
8
8
8
% G
% His:
0
0
0
8
0
0
0
15
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
8
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
8
0
0
0
0
0
0
0
15
8
8
0
8
0
0
% L
% Met:
8
8
0
0
0
0
8
0
8
0
0
0
8
0
0
% M
% Asn:
22
15
8
15
0
15
0
0
0
0
8
0
8
0
0
% N
% Pro:
0
0
8
8
0
8
0
8
0
0
15
15
8
0
15
% P
% Gln:
8
0
0
8
0
0
0
8
15
15
0
22
8
36
8
% Q
% Arg:
0
8
8
0
36
0
0
0
0
0
0
8
15
8
50
% R
% Ser:
0
15
8
8
0
0
29
29
0
15
0
8
8
29
8
% S
% Thr:
0
8
0
15
8
0
0
8
15
0
0
8
0
8
15
% T
% Val:
0
8
8
0
8
8
0
8
0
8
0
0
0
15
0
% V
% Trp:
15
0
8
0
8
0
0
0
0
0
29
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _